Faculty & Staff

Marsha Rolle

Assistant Professor

Faculty Listing
Office: Life Sciences and Bioengineering Center, 4011
Phone: +1-508-831-4145
Fax: +1-508-831-4121
mrolle@wpi.edu

Educational Background

B.S., Brown University, 1995
Ph.D., University of Washington, Seattle, 2003

Research & Teaching Interests

Cardiovascular tissue engineering; Cell-based tissue regeneration and repair; Cell-mediated ECM synthesis and assembly; Delivery and control of ECM genes

Research

Research in the Rolle lab is focused on developing genetic and cellular engineering approaches to control extracellular matrix (ECM) synthesis in tissue engineered constructs, and to quantify the effects of ECM manipulation on the mechanical and physiological properties of engineered tissues. In addition to improving the function of engineered tissues, these studies may lead to development of novel materials and cell and gene delivery systems that promote tissue repair and regeneration in situ.

Recent Publications

Jong Y, Jacob J, Yip K-P, Gardner G, Seitelman E, Whitney M, Mathiowitz E. (1997) Controlled release of plasmid DNA. J Controlled Release 47(2): 123-134.
Whitney ML, Otto KG, Blau CA, Reinecke H, Murry CE. (2001) Control of myoblast proliferation with a synthetic ligand. J Biol Chem 276(44): 41191-41196.
Murry CE, Whitney ML, Reinecke H. (2002) Muscle grafting for the prevention and treatment of heart failure. J Card Fail 8(6 Suppl): S532-541.
Stevens K*, Rolle MW*, Minami E, Ueno S, Nourse M, Virag J, Reinecke H, Murry CE. (2007) Chemical dimerization of fibroblast growth factor receptor-1 induces myoblast proliferation, increases intracardiac graft size, and reduces ventricular dilation in infarcted hearts. Hum Gene Ther 18(5): 401-412.. (*Authors contributed equally.)

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Honors & Awards

Distinguished Teaching Assistant, Dept. of Bioengineering, University of Washington, 2002
Young Investigator Award of the American Heart Association Council on Basic Cardiovascular Science, 2003
Outstanding Female Engineer, University of Washington Society of Women Engineers, 2003
Ruth L. Kirschstein National Research Service Award, National Heart, Lung and Blood Institute, National Institutes of Health, 2006

Years of Service at WPI

Assistant Professor, Worcester Polytechnic Institute, 2007-

Professional Experience & Activities

Research Technician, Sulzer Innotec (Zimmer Biologics, Inc.), Austin, TX, 1996-1997
Research Scientist, Sulzer Innotec (Zimmer Biologics, Inc.), Austin, TX, 1997-1998
Senior Fellow, Pathology, University of Washington, Seattle, WA, 2003-2004
Postdoctoral Fellow, Benaroya Research Institute, Seattle, WA, 2004-2007

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