Structural Characterization of Tissue Using Magnetic Resonance Imaging (Helmer)
Description of the Research
I use magnetic resonance parameters such as T1 and T2 and intrinsic parameters such as the diffusion coefficient of endogenous water to characterize normal and pathological tissue. To this end I have used model systems such as bead packs and yeast-cell packs, in-vivo systems such as murine tumor models and rat models of stroke, and ex-vivo systems such as rabbit tendons. My areas of interest include: identification of pathology at early timepoints, differentiation of pathological tissue from normal by exploiting differences in structure, and changes to structure due to the normal function of the tissue. I am also involved in the analysis of functional imaging data.
Description of Space, Resource, and Specialty Equipment Used
My research is conducted on a number of magnets, either at WPI or off-campus. Magnets currently used are GE CSI-II 2.0T/45cm system, a Varian 9.4T vertical bore magnet and a GE 1.5T LX clinical magnet. The WPI magnet lab facility includes a wet/dry lab space for experiment preparation and coil building as well as a computing room with a small local-area network of pc's for data analysis.
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