Seminars
Modification of endogenous disease related genes in somatic and stem cells by small DNA fragments
Dieter Gruenert, Ph.D.
Head, Stem Cell Research Program
California Pacific Medical Center
Univ. of San Francisco
San Francisco, CA.
Thursday, April 9, 2009
4:15 P.M.
Life Sciences and Bioengineering Center at Gateway Park
Seminar Room (1002)
(Refreshments at 4:00)
Co-Hosted by WPI Department of Biology & Biotechnology and WPI Bioengineering Institute
Abstract: The presentation will present novel findings on the modification of genomic targets in somatic and stem cells by small DNA fragments (SDFs). This process, termed small fragment homologous replacement (SFHR), has been used to target and modify reporter and endogenous genes. The data presented will outline the targeting of the cystic fibrosis transmembrane conductance regulator (CFTR), the human ß-globin and the HPRT genes in airway epithelial cells (human and mouse), hematopoietic and embryonic stem cells, and lymphoblasts, respectively. The presentation will discuss the potential of combined genetic and cell therapy approaches to treat genetic diseases and the potential mechanisms underlying SFHR.
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Last modified: March 26, 2009 14:31:11