Biology and Biotechnology

BB 1001. INTRODUCTION TO BIOLOGY.

Cat. I
This course consists of an overview of the major concepts of Biology, including: cell theory, bioenergetics, molecular biology, reproduction, nutrition, growth, development, homeostatic controls, and ecological issues. This course is intended for non-BB majors who want a broad overview of contemporary Biology with emphasis on human issues. This course does not count towards distribution requirements for BB majors.
Lecture and conference. Recommended background: high school or introductory college level chemistry.

BB 1010. GENERAL BIOLOGY I.

Cat. I
This course is the first introductory biology course for BB and health science pre-professional majors. Important concepts in molecular, cellular, and organismal biology will be studied. Engineering students desiring to meet science distribution requirements should take BB 1001.
Recommended background: high school biology, CH 1010, and CH 1020.

BB 1020. GENERAL BIOLOGY II

Cat. I
This course is a continuation of BB 1010, intended for BB and health sciences pre-professional majors. Important concepts in organismal, population, evolutionary, and ecological biology will be studied. Engineering students desiring to meet science distribution requirements should take BB 1001.
Recommended background: BB 1010 and CH 1020.

BB 1101. ENVIRONMENTAL BIOLOGY.

Cat. I
The ecosystem is presented and evaluated as the basic functional unit of the environment. Comparisons are made of terrestrial, aquatic, and marine ecosystems. Ecosystem modeling is introduced and used to evaluate stressed ecosystems. Contemporary environmental topics are emphasized. This course is suitable for a biology major who is interested in an overview of ecology with emphasis on environmental issues, or for the non-biology major who may wish to combine it with BB 1001 for a coordinated two-course sequence in science.
Lecture. Recommended background: BB 1001 or a working knowledge of the basic principles and concepts of biology.

BB 2002. MICROBIOLOGY.

Cat. I
The various organisms making up the protists and viruses, their taxonomy, morphology, and physiology are studied. Special attention will be given to those organisms which are of ecological concern or serve a useful industrial purpose. The importance of microbes in public health problems will be presented. This course is designed for all biology majors and for other students who seek a good general education in modern biology.
Recommended background: BB 1010, BB 1020, and BB 2550 or equivalent. A basic understanding of elementary biochemical processes is desirable.

BB 2020. ZOOLOGY.

Cat. II
This course is a survey of the animal kingdom with an emphasis on its history and organization. Particular attention is paid to special structures and mechanisms evolved by selected representatives of major phyla for solving problems of life in various environments.
Recommended background: BB 1010 and BB 1020.
This course will be offered in 1996-97 and in alternate years thereafter.

BB 2030. BOTANY.

Cat. II
An introductory course stressing general concepts, physiology, anatomical and taxonomic links, and uses of the major plant phyla in both society and industry. Some emphasis will be given to economically important species chosen from both agronomic and nonagronomic situations.
Recommended background: BB 1010 and BB 1020.
This course will be offered in 1995-96 and in alternate years thereafter.

BB 2550. CELL BIOLOGY.

Cat. I
This intermediate level course, required for all BB majors, presents the fundamental aspects of cell structure and function, the foundation of all fields of modern biology.
Topics include: cell complexity and organizational hierarchy, evolution of the cell, cell surface, plasma membrane, single and double cytoplasmic membrane systems, nuclear fusion and hybridomas, cytoskeleton, cell growth, and differentiation.
Recommended background: BB 1010, BB 1020, CH 1030.

BB 2920. GENETICS.

Cat. I
This intermediate level course presents the principles and experimental proofs leading to our understanding of DNA as genetic material. Quantitative analysis of patterns of inheritance, mechanisms of gene exchange, phenotypic expression, macromolecular structure, control mechanisms, and population phenomena in prokaryotes, plants, and animals including humans are considered. This course is designed for all biology majors.
Recommended background: BB 1010, BB 1020 and BB 2550 or equivalent.

BB 2940. EXPERIMENTAL BIOLOGY I.

Cat. 1
The lab exercises in this course have been selected to provide the skills needed to study living organisms at the cellular level, and to emphasize the basic principles of Biology. Students will gain experience with procedures, equipment and lab skills common to all Biology fields. Emphasis is on precise data collection, analysis and interpretation of biological data. This course is designed for Biology/Biotechnology majors and other life science preprofessionals. One lecture and lab per week for 2 terms (i.e. 1/3 unit per 14 weeks, A & B terms).
This course may not be taken for less than 1/3 unit of credit except with the prior approval of the instructor.
Recommended background: BB 1010, BB 1020, CH 1030. Concurrent enrollment in BB 2550 (A) and BB 2002 (B).

BB 2950 EXPERIMENTAL BIOLOGY II.

Cat. I
A continuation of Experimental Biology I with lab exercises selected to emphasize the skills needed to study living organisms and their diversity. These exercises will emphasize the principles and techniques of genetics and microbiology, as well as the diversity of the biological flora and fauna. Unique aspects of living organisms will be featured as opportunities for use in Biotechnology. One lecture and lab per week for 2 terms (i.e. 1/3 unit per 14 weeks, C & D terms).This course may not be taken for less than 1/3 unit of credit except with the prior approval of the instructor.
Recommended background: BB 2940. Concurrent enrollment in BB 2920 (C) and BB 2020/30 (D).

BB 3100. PHYSIOLOGY I.

Cat. I
The general and specialized physiological functions of animal cells will be explored. Topics covered will include cellular energetics, cell environments, transmembrane transport, membrane permeability, electrically excitable cells, mechanisms of hormone action, intercellular communication, and movement and the production of force.
Recommended background: BB 1001 or BB 1010 and CH 1030.

BB 3101. PHYSIOLOGY II.

Cat. I
This course examines the integrated functions performed by cells organized into tissues, organs, and systems, with special reference to the human organism. The nervous, skeleto-muscular, circulatory, respiratory, digestive, endocrine, excretory, and reproductive systems of the human body, and their integration, will be covered.
Recommended background: BB 3100.

BB 3620. DEVELOPMENTAL BIOLOGY.

Cat. II
This advanced level course uses a seminar format to discuss current research articles describing developmental mechanisms in a variety of biological systems. Concepts such as embryonic induction, determinism, pattern morphogenesis, and organogenesis are examined at the molecular, cellular, tissue, and organismal levels.
Recommended background: BB 1010, BB 1020, BB 2002, BB 2550, BB 2920.
This course will be offered in 1996-97 and in alternate years thereafter.

BB 4007. CELL CULTURE.

Cat. I
This course presents the principles and experimental protocols needed for the in vitro culture of plant and mammalian cells. Subjects covered include: media composition and preparation, cell surface sterilization, antibiotics, cell quantification, micropropagation, cyropreservation and the influence of environmental factors on growth and development.
Recommended background: BB 1020, BB 2002, BB 2020, BB 2030, BB 2550.

BB 4010. ADVANCED MOLECULAR GENETICS.

Cat. I
Topics in molecular genetics are presented using microbial systems as models. The structure, function and synthesis of DNA and the results of mutation, recombination and repair are emphasized. Simple bacteria and their plasmids, transposable elements and phages are discussed as experimental models.
Recommended background: BB 2002, BB 2920, BB 4910.

BB 4050. FERMENTATION BIOLOGY.

Cat. I
This course deals with the theory and practice by which microbial metabolism can be harnessed for the production of chemicals and fuels. Students will design and evaluate a bench-scale fermentation process. This course is the second in an integrated course sequence in bioprocess technology.
Recommended background: prior knowledge of BB 2002 (Microbiology) and CH 4110 (Biochemistry); concurrent registration in CH 4120.

BB 4060. PROTEIN PURIFICATION AND DOWNSTREAM PROCESSING.

Cat. I
This course consists of a thorough treatment of state-of-the-art techniques in protein purification as practiced in the biotechnology industry. The student will gain experience in the design and implementation of protein purification schemes. This course is intended for both biology and biotechnology, and engineering majors. This course is the third in an integrated course sequence in bioprocess technology.
Recommended background: prior knowledge of Biochemistry (CH 4110, 4120) will be assumed.

BB 4550. ADVANCED CELL BIOLOGY.

Cat. I
This advanced level course uses a seminar format to discuss current research articles describing mechanisms by which cells reproduce, develop, and interact. Particular emphasis is placed on current cellular and molecular pathological mechanisms of autoimmune diseases such as systemic lupus erythematosus and myasthenia gravis.
Recommended background: BB 3100, BB 3101, BB 4910, CH 4110, CH 4120.

BB 4910/CH 4130. MOLECULAR BIOLOGY/BIOCHEMISTRY III.

Cat. I
The structure, function and biosynthesis of DNA, RNA and proteins are the chief topics of this course. Both prokaryotic and eukaryotic systems are examined. The nature of the genome and the genetic code, the structure and expression of selected genes and the regulation of genetic expression are emphasized.
Recommended background: prior knowledge of Cell Biology (BB 2550), Genetics (BB 2920), and Biochemistry (CH 4110, CH 4120).

BB 4950. RECOMBINANT DNA BIOCHEMISTRY.

Cat. I
This course presents both theory and applications in recombinant DNA methodology. Topics covered include enzymology of DNA manipulation; construction and isolation of recombinants; plasmid and bacteriophage vectors; structural analysis of cloned DNA. This course is the first in an integrated course sequence in bioprocess technology.
Recommended background: prior knowledge of (BB 2002), (BB 2550), (BB 2920), and (BB 4910) will be assumed. Advanced Molecular Genetics (BB 4010) is very strongly recommended.

IS4 BB SPECIAL TOPICS

Cat. I
Experimental courses, special conferences and seminars are offered by advance arrangement only.


Graduate Biology and Biotechnology Courses of Interest to Undergraduates


The following graduate courses are open to undergraduates with special permission (see department chairman and course instructor).

BB 501. BIOLOGY SEMINAR.

Selected topics from the current literature are reviewed and evaluated.
One (1) credit/semester.

BB 502. TECHNIQUES IN ELECTRON MICROSCOPY.

This course will present the theory of operation, applications, and use of scanning and transmission electron microscopy in biology. Recent original articles from the biological literature will illustrate the applications of these techniques to research. Students will prepare their own specimens for both kinds of electron microscopes and employ the standard preparative techniques including fixation, dehydration, staining, critical point drying, vacuum evaporation, embedding and sectioning. Associated photographic methods will also be introduced. Since this course is basically concerned with the development of laboratory skills, formal class periods will be limited. Three (3) credits/semester.
Recommended background: a knowledge of Cell Biology (BB 2550) and conventional light microscopic methods.
This course will be offered in 1995-96 and in alternate years thereafter.

BB 509. SCALE-UP OF FERMENTATION AND DOWNSTREAM PROCESSING.

This course will provide students with hands-on training in the principles and methods necessary to scale up protein production and purification from bench to pilot scale. Students will design and carry out a protein production and purification scheme at the 50 liter scale. Emphasis will be on laboratory work, backed up by understanding of the relevant theory.


[Contents]

webmaster@wpi.edu
Last Modified: Thu Jul 8 14:56:34 EDT 1999