Title page for E-project-011309-180004

Project Type	MQP
Submission date	2009-01-13
Authors	Samuel Luke Raj, BBT Dhruv Sarin, BBT
URN	E-project-011309-180004
Sponsor	Umass Med
Title	A GAIN OF FUNCTION MUTATION IN THE P/Q TYPE VOLTAGE GATED Ca2+ CHANNEL, UNC-2, STIMULATES ACETYLCHOLINE RELEASE IN CAENORHABDITIS ELEGANS
Advisor	Adams, David S., BB
Availability	unrestricted
Abstract zf35 is a mutation in the unc-2 gene of C. elegans that causes a hyperactive phenotype. unc-2 encodes the alpha-1a subunit of a P/Q type calcium channel involved in synaptic transmission in C. elegans. Double mutants were constructed of zf35 and known synaptic transmission mutants egl-30, unc-13, snt-1, and unc-31, to determine how zf35 affects neurotransmitter release. Also, a genetic screen was done to identify mutations that suppress the zf35 phenotype, revealing novel genes in this pathway. We conclude that zf35 mutants have defects in the presynaptic pathway.
Files	DhruvandSamuelMQP.pdf

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