Project Type MQP Submission date 2007-02-25 Author Kerri L George, BC URN E-project-022507-213608 Sponsor Dr. Robert Zurier and Dr. Jane Lian Title Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. Advisor Rulfs, Jill, BB Availability unrestricted Abstract
Ajulemic acid (AjA) is a synthetic analog of the tetrahydrocannabinol (THC) metabolite THC-11-oic acid. AjA reduces release of the inflammatory cytokine interleukin-1b (IL-1b) from peripheral blood and synovial fluid monocytes, and prevents bone degradation in a rat model of inflammatory arthritis. Because preosteoclasts are of monocyte lineage, we initiated these studies to understand the direct effects of AjA on both osteoclast differentiation and activity. In this paper, we demonstrate that AjA suppresses osteoclastogenesis in vitro in a concentration dependent manner.
Files finalmqp.pdf
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