Title page for E-project-022508-140214

Project Type MQP

Submission date 2008-02-25

Author
Bryan J Egge, BIO

URN E-project-022508-140214

Sponsor UMass Med

Title Macrophage Tropism and Antibody Neutralization Resistance of HIV-1 is Conferred by the Envelope Protein gp120

Advisor
Adams, David S., BB

Availability unrestricted

Abstract
This MQP investigated the viral tropism and neutralizing antibody sensitivities of gp120 and gp41 sequences of three parental HIV-1 strains (Q43-378.2, Q43-378.c, and SQ43-380.1) isolated from a single patient, and of various engineered chimeras. The data indicate that gp120 alone is able to confer macrophage tropism, while gp41 has no noticeable effect on tropism. The data further indicate that gp41 has no visible effect on the resistance to a b12 antibody that reacts with the CD4-binding domain on gp-120, and that gp120 sequences are the most likely cause of neutralization resistance.

Files
MQP.pdf

Browse by Author | Browse by Department | Search all available E-projects

Questions? Email project-questions@wpi.edu
Maintained by webmaster@wpi.edu

Project Type	MQP
Submission date	2008-02-25
Author	Bryan J Egge, BIO
URN	E-project-022508-140214
Sponsor	UMass Med
Title	Macrophage Tropism and Antibody Neutralization Resistance of HIV-1 is Conferred by the Envelope Protein gp120
Advisor	Adams, David S., BB
Availability	unrestricted
Abstract This MQP investigated the viral tropism and neutralizing antibody sensitivities of gp120 and gp41 sequences of three parental HIV-1 strains (Q43-378.2, Q43-378.c, and SQ43-380.1) isolated from a single patient, and of various engineered chimeras. The data indicate that gp120 alone is able to confer macrophage tropism, while gp41 has no noticeable effect on tropism. The data further indicate that gp41 has no visible effect on the resistance to a b12 antibody that reacts with the CD4-binding domain on gp-120, and that gp120 sequences are the most likely cause of neutralization resistance.
Files	MQP.pdf