Title page for E-project-031407-165815

Project Type MQP

Submission date 2007-03-14

Authors
David P Pesce, PH
Jeffrey M Sanders, PH

URN E-project-031407-165815

Title Protein Dynamics: Probing biological processes at the molecular level

Advisor
Burnham, Nancy A., PH

Availability unrestricted

Abstract
Proteins are essential for all cellular processes. Hemoglobin is one of the most well studied proteins and is the standard model for allosteric regulation. Allostery is an important, yet poorly understood, component of biochemistry. Using Normal Mode Analysis (NMA), the dynamics of scapharca dimeric hemoglobin, an allosteric protein,have been simulated and correlate with previous crystallographic data. This indicates that NMA may be a useful tool for predicting early intermediate structures and explaining allosteric regulation at the molecular level.

Files
MQPFINALDRAFT.pdf

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Project Type	MQP
Submission date	2007-03-14
Authors	David P Pesce, PH Jeffrey M Sanders, PH
URN	E-project-031407-165815
Title	Protein Dynamics: Probing biological processes at the molecular level
Advisor	Burnham, Nancy A., PH
Availability	unrestricted
Abstract Proteins are essential for all cellular processes. Hemoglobin is one of the most well studied proteins and is the standard model for allosteric regulation. Allostery is an important, yet poorly understood, component of biochemistry. Using Normal Mode Analysis (NMA), the dynamics of scapharca dimeric hemoglobin, an allosteric protein,have been simulated and correlate with previous crystallographic data. This indicates that NMA may be a useful tool for predicting early intermediate structures and explaining allosteric regulation at the molecular level.
Files	MQPFINALDRAFT.pdf