Project Type MQP Submission date 2008-04-21 Author Christina L Ernst, cernst41@WPI.EDU, BIO URN E-project-042108-144532 Title Structural and Functional Dissection of Kekkon5: A Putative Novel Component of the Cellular Adhesion Machinery Advisor Duffy, Joseph B, BB Availability unrestricted Abstract
Cellular adhesion is an essential factor in development, serving both structural and communicatory functions, defects in which have been implicated in a wide range of diseases, including cardiovascular and neurodegenerative disorders. Kekkon5, a transmembrane protein in Drosophila containing the atypical combination of leucine-rich repeats and immunoglobulin domains, has been implicated in cellular adhesion and related signaling pathways. Deletion studies with Kekkon5 have demonstrated the necessity of both extracellular and intracellular domains for full activity and function.
Files CErnstMQPD08.pdf
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