Title page for E-project-042305-151657

Project Type MQP

Submission date 2005-04-23

Author
Nina E Mallozzi, BIO

URN E-project-042305-151657

Title Neuromuscular Transmitters in the Horseshoe Crab

Advisor
Gibson, Daniel G, BB

Availability unrestricted

Abstract
Most arthropod species use glutamate as their principal excitatory neuromuscular transmitter, but we present evidence that this role is played by acetylcholine in walking legs of the horseshoe crab, Limulus polyphemus. Agonists of cholinergic transmission enhance neuronally evoked contractions, while antagonists inhibit these contractions. Videorecording and electrical recording were both used to gather this data. Considering the lineage of arthropod taxa, cholinergic innervation of arthropod muscle may predate the glutamatergic innervation of crustaceans and insects.

Files
nmallozzi.pdf

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Project Type	MQP
Submission date	2005-04-23
Author	Nina E Mallozzi, BIO
URN	E-project-042305-151657
Title	Neuromuscular Transmitters in the Horseshoe Crab
Advisor	Gibson, Daniel G, BB
Availability	unrestricted
Abstract Most arthropod species use glutamate as their principal excitatory neuromuscular transmitter, but we present evidence that this role is played by acetylcholine in walking legs of the horseshoe crab, Limulus polyphemus. Agonists of cholinergic transmission enhance neuronally evoked contractions, while antagonists inhibit these contractions. Videorecording and electrical recording were both used to gather this data. Considering the lineage of arthropod taxa, cholinergic innervation of arthropod muscle may predate the glutamatergic innervation of crustaceans and insects.
Files	nmallozzi.pdf