Project Type MQP Submission date 2008-04-23 Authors Jennifer M Gosselin, BIO Sean Michael O'Toole, BIO URN E-project-042308-192844 Title MIG-10, an Adapter Protein, Interacts with ABI-1, a Component of Actin Polymerization Machinery Advisor Ryder, Elizabeth F, BIO Availability unrestricted Abstract
MIG-10 is a protein known to be involved in axon guidance and neuronal migration in early development in C. elegans. In an effort to better understand the protein's function, this project used the yeast two hybrid system to screen a cDNA library (representing the entire C. elegans genome) for proteins with which MIG-10 interacts. The idea is if we can associate it with proteins of known function, we'll have a better idea as to what MIG-10 itself does. Our research revealed that MIG-10 interacts with (among other proteins) ABI-1, which is a component of actin polymerization machinery.
Files MQP_OToole.Gosselin-resubmission.pdf
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