Title page for E-project-042408-005150

Project Type MQP

Submission date 2008-04-24

Authors
Vincent L Kan, BE
Imran I Malek, BE
Sean A McDermott, BE
Lynn Worobey, BE

URN E-project-042408-005150

Title Effective Stiffness of Suspended Gels

Advisors
Billiar, Kristen, BE
Rolle, Marsha W, BE

Availability unrestricted

Abstract
In chronic wound healing there is an over-production of myofibroblasts, resulting from the stiffness of the surrounding environment. Wound healing is studied in vitro using collagen gels and stiffness is often determined using destructive methods. A device was developed to determine stiffness non-destructively by using transverse loading methods to measure force and displacement. The device was validated by comparing results with literature on transverse loading. Collagen gels were tested to demonstrate repeatability and illustrate compatibility with relevant wound healing models.

Files
KLB0701.pdf

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Project Type	MQP
Submission date	2008-04-24
Authors	Vincent L Kan, BE Imran I Malek, BE Sean A McDermott, BE Lynn Worobey, BE
URN	E-project-042408-005150
Title	Effective Stiffness of Suspended Gels
Advisors	Billiar, Kristen, BE Rolle, Marsha W, BE
Availability	unrestricted
Abstract In chronic wound healing there is an over-production of myofibroblasts, resulting from the stiffness of the surrounding environment. Wound healing is studied in vitro using collagen gels and stiffness is often determined using destructive methods. A device was developed to determine stiffness non-destructively by using transverse loading methods to measure force and displacement. The device was validated by comparing results with literature on transverse loading. Collagen gels were tested to demonstrate repeatability and illustrate compatibility with relevant wound healing models.
Files	KLB0701.pdf