Project Type MQP Submission date 2008-04-24 Authors John Gerard Bray, Mr., BE Wai-Mun Leung, BE Kene Mgbojikwe, BE Jayanth Shivaprakash, BE URN E-project-042408-114607 Title Delivery Vehicle and Mechanism for Human Mesenchymal Stem Cells Advisor Gaudette, Glenn R, BE Availability unrestricted
Several studies have shown that human mesenchymal stem cells (hMSCs)have the potential to be the futute of regenerative medicine based on their ability to rebuild diseased or damaged tissues. The difficulty involved with hMSCs is delivering these cells to the injured tissue site. Injection is the preferred method, but it has been shown that simple injection of hMSCs in media results in extreme turbulent flow, thus killing the cells. Hydrogels have been researched as a form of vehicle for hMSC transport. However, the delivery of the gel and cell viability remain a problem. This project aims to seek the best overall hydrogel to act as the vehicle as well as a delivery mechanism that allows for simple, safe and convenient transport of hMSCs.
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