Project Type MQP Submission date 2012-04-24 Author John D Neary, BIO URN E-project-042412-111842 Center UMMC / University of Massachusetts Medical Center Sponsor Dr. Schahram Akbarian Title White Matter Neurons: mRNA Expression and Analysis Advisor Adams, David S., BB Availability unrestricted
Current neurological research indicates that the improper migration of neurons into subcortical white matter in humans may play a role in the etiology of schizophrenia, major depressive disorder, autism, and other psychological disorders. The purpose of this project was to isolate mRNA from both white and gray matter samples from mentally ill and healthy individuals in an effort to elucidate mRNA gene expression differences between white matter neurons and gray matter neurons, if any. These differences in gene expression may open new avenues of research and treatment in patients suffering from psychiatric disorders with genetic etiologies.
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