Project Type MQP Submission date 2006-04-25 Author Peter T Lapen, BIO URN E-project-042506-194241 Sponsor Dr. Aldo Rossini, M.D. and Dr. Rita Bortell, PhD. Title HIGHER LEVELS OF ER STRESS PROTEINS OCCUR IN PANCREATIC ISLETS OF DIABETIC PRONE VERSUS RESISTANT RATS Advisor Adams, David S., BB Availability unrestricted Abstract
Bio Breeding (BB) rats are a well known model for juvenile diabetes. Diabetic prone (DP) and resistant (DR) lines were created by in-breeding. DP rats spontaneously develop diabetes via pancreatic beta cell death, but the exact mechanism remains unknown. This project investigated cellular levels of several proteins thought to play a role in endoplasmic reticulum (ER) stress, which could lead to beta cell death. Levels were compared in pancreatic islets from DP and DR thapsigargin-stressed and non-stressed rats by western blot and real-time PCR assays. The results indicated that DP rats manifested higher levels of ER stress proteins.
Files LapenPeterMQP2006.pdf
Browse by Author | Browse by Department | Search all available E-projects
![[WPI]](/Buttons/seal.gif){kind=small}
![[Library]](/Academics/Library/Buttons/lib.gif){kind=small}
![[Home]](/Buttons/home.gif){kind=small}
![[Top]](/Buttons/top.gif){kind=small}