Title page for E-project-042507-000730

Project Type MQP

Submission date 2007-04-25

Author
Jenna Elizabeth Geddes, BIO

URN E-project-042507-000730

Sponsor UMASS Medical School

Title HIGHER LEVELS OF ER STRESS IN DIABETES-PRONE RATS PLAYS A ROLE IN APOPTOTIC SIGNALING

Advisor
Adams, David S., BB

Availability unrestricted

Abstract
Biobreeding diabetes-prone (BBDP) rats exhibit a severe T cell lymphopenia, which may be linked to cellular stress. Expression of GRP78, an ER stress regulatory protein, was examined in various T cell populations of BBDP and BioBreeding diabetes-resistant rats (BBDR). Flow cytometry analysis revealed increased ER stress in all mature populations of T cells examined from the BBDP rat, but not in the immature thymocytes. These results suggest that increased ER stress in BBDP rats may play a role in apoptotic signaling that leads to T cell lymphopenia.

Files
Jenna_Geddes_MQPFinal.pdf

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Project Type	MQP
Submission date	2007-04-25
Author	Jenna Elizabeth Geddes, BIO
URN	E-project-042507-000730
Sponsor	UMASS Medical School
Title	HIGHER LEVELS OF ER STRESS IN DIABETES-PRONE RATS PLAYS A ROLE IN APOPTOTIC SIGNALING
Advisor	Adams, David S., BB
Availability	unrestricted
Abstract Biobreeding diabetes-prone (BBDP) rats exhibit a severe T cell lymphopenia, which may be linked to cellular stress. Expression of GRP78, an ER stress regulatory protein, was examined in various T cell populations of BBDP and BioBreeding diabetes-resistant rats (BBDR). Flow cytometry analysis revealed increased ER stress in all mature populations of T cells examined from the BBDP rat, but not in the immature thymocytes. These results suggest that increased ER stress in BBDP rats may play a role in apoptotic signaling that leads to T cell lymphopenia.
Files	Jenna_Geddes_MQPFinal.pdf