Project Type MQP Submission date 2007-04-25 Authors Marsha Rebecca D'Souza, BIO Demetra Orthodoxou, BC URN E-project-042507-085122 Sponsor Brudnick Neuropsychiatric Research Institute-UMass Title An endocytic signal for the potassium channel KCNK3 Advisor Ryder, Elizabeth F, BB Availability unrestricted
Membrane trafficking is a major cellular mechanism for the regulation of surface expression of plasma membrane proteins. Recently, a carboxyl terminus motif, FREKLAYAIA, has been shown to control the internalization of the dopamine transporter (DAT), a critical protein in synaptic transmission. Sequence comparison across BLAST identified a similar carboxyl motif, SREKLQYSIP, in the leak potassium channel KCNK3. The current study tested whether this motif was necessary and sufficient for the internalization of the channel. Our results suggest that the carboxyl terminus of KCNK3 is sufficient for the internalization of an endocytic deficient reporter molecule (Tac), and that the SREKLQYSIP motif may be necessary for this internalization.
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