Title page for E-project-042507-233801

Project Type	MQP
Submission date	2007-04-25
Authors	Rachael A. Buteau, BE Thomas W Jenket, BE Christina Mezzone, BE
URN	E-project-042507-233801
Title	Design of a High-Throughput Molecular Diffusion Device to Study Molecular Transport through Collagen Membranes
Advisor	Pins, George, BE
Availability	unrestricted
Abstract Diffusion studies allow scientists to gain a better understanding of the function and structure of membranes. However, these diffusion studies can be time consuming and costly when using current devices on the market. Our goal was to design and validate an affordable high-throughput molecular diffusion system to characterize membranes. Our device was validated using glucose, bovine serum albumin (BSA), and gamma globulin. The calculated coefficients were 5.58x10-6 cm2/s, 7.08x10-8 cm2/s, and 4.83x10-8 cm2/s for glucose, BSA, and gamma globulin, respectively. Diffusion coefficients were shown to be the same for our device and a marketed device and are comparable to published values, suggesting that our device will serve as a facile tool to rapidly characterize engineered membranes.
Files	Design_of_a_Molecular_Diffusion_System.pdf

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