Project Type MQP Submission date 2012-04-25 Authors Michael Aschettino, BE Steven Joseph Delfosse, BE Katherine Marie Larson, BE Caitlin Rebecca Quinn, BE URN E-project-042512-122709 Title Biomimetic Skeletal Muscle Tissue Model Advisors Page, Raymond L., BE Jain, Anjana, BE Availability unrestricted
In vitro tissue modeling of skeletal muscle has a potential role in understanding muscle tissue physiology. Current systems contain limitations including the presence of extracellular matrix and diffusion limitations. Our team developed a system that allows for sterile 3D tissue development, mimics in vivo attachment points, has a scaffold-less construction, and can mechanically stimulate developing muscle tissue in vitro. We believe this in vitro tissue model will not only allow a better understanding of developing muscle tissue, but can also be used as a screening modality for evaluation of future therapeutic treatments for muscle diseases and volumetric muscle loss.
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