Title page for E-project-042512-163416

Project Type MQP

Submission date 2012-04-25

Authors
Peter M Chunis, peterchunis@WPI.EDU, BE
Yun Qiao, BE
Disha Sood, BE
Matthew Aaron Whitman, BE

URN E-project-042512-163416

Title Implantable Biological Pacemaker for Permanent Autonomous Pacing of the Heart

Advisor
Gaudette, Glenn R., BE

Availability unrestricted

Abstract
Electronic pacemakers are widely used to treat cardiac pacing problems, but the devices have inherent limitations. Hyperpolarization-activated cyclic nucleotide gated (HCN) transfected human mesenchymal stem cells (hMSCs) show promise as a solution to these problems, but these cells must be contained at the implant site to preserve functionality and patient safety. This project aims to design and fabricate a device that is capable of preventing cell migration while allowing for cell-cell interactions and enabling minimally invasive delivery. A heat-sealed, micropatterned scaffold was created to achieve mechanical strength and cell retention while maintaining low thickness necessary for cell interactions. Testing suggests cells can be safely restrained during and after implantation.

Files
Implantable_Biological_Pacemaker_for_Permanent_Autonomous_Pacing_of_the_Heart.pdf

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Project Type	MQP
Submission date	2012-04-25
Authors	Peter M Chunis, peterchunis@WPI.EDU, BE Yun Qiao, BE Disha Sood, BE Matthew Aaron Whitman, BE
URN	E-project-042512-163416
Title	Implantable Biological Pacemaker for Permanent Autonomous Pacing of the Heart
Advisor	Gaudette, Glenn R., BE
Availability	unrestricted
Abstract Electronic pacemakers are widely used to treat cardiac pacing problems, but the devices have inherent limitations. Hyperpolarization-activated cyclic nucleotide gated (HCN) transfected human mesenchymal stem cells (hMSCs) show promise as a solution to these problems, but these cells must be contained at the implant site to preserve functionality and patient safety. This project aims to design and fabricate a device that is capable of preventing cell migration while allowing for cell-cell interactions and enabling minimally invasive delivery. A heat-sealed, micropatterned scaffold was created to achieve mechanical strength and cell retention while maintaining low thickness necessary for cell interactions. Testing suggests cells can be safely restrained during and after implantation.
Files	Implantable_Biological_Pacemaker_for_Permanent_Autonomous_Pacing_of_the_Heart.pdf