Title page for E-project-042606-114459

Project Type MQP

Submission date 2006-04-26

Author
Scott John Beaurivage, BC

URN E-project-042606-114459

Title Specific Inhibition of Rac1 Activation

Advisor
Adams, David S., BB

Availability unrestricted

Abstract
Rac1 is a member of a family of small GTPases that are primarily responsible for cellular motility and morphology. Activation of Rac1 by Rac-specific guanine nucleotide exchange factors (GEFs) is thought to be important for the metastasis of cancer cells. The scope of this project was to synthesize a minimal extended peptide sequence that would block interaction between Rac1 and the Rac1-specifice exchange factor GEF-H1. Inhibition of Rac1 activation by Rac-specific GEFs would be a useful tool for the study of Rac-mediated cellular processes and may ultimately result in cancer therapeutics.

Files
MQP.pdf

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Project Type	MQP
Submission date	2006-04-26
Author	Scott John Beaurivage, BC
URN	E-project-042606-114459
Title	Specific Inhibition of Rac1 Activation
Advisor	Adams, David S., BB
Availability	unrestricted
Abstract Rac1 is a member of a family of small GTPases that are primarily responsible for cellular motility and morphology. Activation of Rac1 by Rac-specific guanine nucleotide exchange factors (GEFs) is thought to be important for the metastasis of cancer cells. The scope of this project was to synthesize a minimal extended peptide sequence that would block interaction between Rac1 and the Rac1-specifice exchange factor GEF-H1. Inhibition of Rac1 activation by Rac-specific GEFs would be a useful tool for the study of Rac-mediated cellular processes and may ultimately result in cancer therapeutics.
Files	MQP.pdf