Title page for E-project-042607-111156

Project Type MQP

Submission date 2007-04-26

Authors
Linsley A Kelly, BIO
Brendan M O'Brien, BIO

URN E-project-042607-111156

Title C. elegans Mutants with Decreased Pathogenic Response to Yeast

Advisors
Politz, Samuel M, BB
Prusty, Reeta, BC

Availability unrestricted

Abstract
One of the largest problems in medicine today is fungal pathogenesis. The eukaryotic nature of fungi is similar to their hosts, which include humans. Due to these similarities it is difficult to develop novel drugs against their infection. Through the development of a host-pathogen system, host factors involved in resistance may be identified. Saccharomyces cerevisiae causes a pathogenic response in wild type Caenorhabditis elegans, characterized as swelling of the anal region of the organisms. We developed an assay to test the immune response of mutant strains of C. elegans. Eight out of thirteen mutant strains displayed a deformed anal region (Dar) on the fourth day of the assay. One mutant strains, bus-4, had no visible pathogenic response to the S. cerevisiae.

Files
KellyOBrienMQP.pdf

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Project Type	MQP
Submission date	2007-04-26
Authors	Linsley A Kelly, BIO Brendan M O'Brien, BIO
URN	E-project-042607-111156
Title	C. elegans Mutants with Decreased Pathogenic Response to Yeast
Advisors	Politz, Samuel M, BB Prusty, Reeta, BC
Availability	unrestricted
Abstract One of the largest problems in medicine today is fungal pathogenesis. The eukaryotic nature of fungi is similar to their hosts, which include humans. Due to these similarities it is difficult to develop novel drugs against their infection. Through the development of a host-pathogen system, host factors involved in resistance may be identified. Saccharomyces cerevisiae causes a pathogenic response in wild type Caenorhabditis elegans, characterized as swelling of the anal region of the organisms. We developed an assay to test the immune response of mutant strains of C. elegans. Eight out of thirteen mutant strains displayed a deformed anal region (Dar) on the fourth day of the assay. One mutant strains, bus-4, had no visible pathogenic response to the S. cerevisiae.
Files	KellyOBrienMQP.pdf