Title page for E-project-042612-103607

Project Type	MQP
Submission date	2012-04-26
Author	Laura C Fineman, BIO
URN	E-project-042612-103607
Sponsor	UMass Medical School
Title	Characterization of Senescence Regulation by Smurf2 and Notch3 in vitro and in vivo
Advisor	Duffy, Joseph B., BB
Availability	restricted
Abstract One of the main functions of a tumor suppressor is to repress cell division, sometimes by inducing cellular senescence. Smurf2 and Notch3 have previously been identified in our laboratory as tumor suppressors in vitro. It is not well understood how these genes regulate senescence. The purpose of this project is to better understand the mechanisms underlying the functions of these genes in senescence. A genetic screen using short hairpin RNAs (shRNAs) was carried out to identify genes downstream of Smurf2 or Notch3 in the senescence pathways. Five candidate genes were further analyzed in fibroblasts. To characterize the function of Smurf2 in senescence in vivo, a Cre-LoxP system was used to study the consequence of Smurf2 overexpression in mice.
Files	lcfMQP_Final.pdf indicates that a file or directory is accessible from the WPI campus network only.

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