Title page for E-project-042612-144641

Project Type MQP

Submission date 2012-04-26

Authors
Tom Clinckemaillie, BE
Franco Antonio Oshiro, foshiro@WPI.EDU, BE
Joseph Michael Worthy, BE

URN E-project-042612-144641

Title Automated Cardiomyocyte Isolation

Advisor
Gaudette, Glenn R., BE

Availability unrestricted

Abstract
Myocardial infarction is characterized by the death of cardiomyocytes, the fundamental contractile units of the heart. Due to the cardiomyocyte's physiological importance, a more efficient and economical alternative to manual cell isolation is needed to obtain cells for in vitro studies. We designed a device that automates the teasing and mechanical agitation of heart tissue to obtain isolated cardiomyocytes. Through testing, our device met design goals for cell yield and viability while greatly reducing overall isolation duration and user interaction.

Files
Automated_Cardiomyocyte_Isolation_Report.pdf

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Project Type	MQP
Submission date	2012-04-26
Authors	Tom Clinckemaillie, BE Franco Antonio Oshiro, foshiro@WPI.EDU, BE Joseph Michael Worthy, BE
URN	E-project-042612-144641
Title	Automated Cardiomyocyte Isolation
Advisor	Gaudette, Glenn R., BE
Availability	unrestricted
Abstract Myocardial infarction is characterized by the death of cardiomyocytes, the fundamental contractile units of the heart. Due to the cardiomyocyte's physiological importance, a more efficient and economical alternative to manual cell isolation is needed to obtain cells for in vitro studies. We designed a device that automates the teasing and mechanical agitation of heart tissue to obtain isolated cardiomyocytes. Through testing, our device met design goals for cell yield and viability while greatly reducing overall isolation duration and user interaction.
Files	Automated_Cardiomyocyte_Isolation_Report.pdf