Title page for E-project-042706-151125

Project Type MQP

Submission date 2006-04-27

Author
Melissa Christine Coonradt, BIO

URN E-project-042706-151125

Sponsor Univeristy of Massachusetts Medical School - Dr. L

Title Alphav Beta6 Integrin Expression in Inflamed & Malignant Prostate

Advisor
Adams, David S., BB

Availability unrestricted

Abstract
Prostate cancer cell functions are regulated by elaborate signaling pathways activated by extracellular stimuli. The integrin family of cell surface receptors is known to activate intracellular pathways in response to signals generated via specific interactions with the extracellular matrix. Through the use of immunohistochemistry and immunoblotting, this study shows that the alpha-v beta-6 integrin is predominately expressed in epithelial cells in human preneoplastic, prostate intraepithelial neoplasia, proliferative inflammatory atrophy lesions and prostatic adenocarcinoma. The results indicate that alpha-v beta-6 is highly expressed in areas with infiltrating leukocytes, and is expressed focally in malignant and some benign prostate glands, but not in normal prostate tissue.

Files
MQP.pdf

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Project Type	MQP
Submission date	2006-04-27
Author	Melissa Christine Coonradt, BIO
URN	E-project-042706-151125
Sponsor	Univeristy of Massachusetts Medical School - Dr. L
Title	Alphav Beta6 Integrin Expression in Inflamed & Malignant Prostate
Advisor	Adams, David S., BB
Availability	unrestricted
Abstract Prostate cancer cell functions are regulated by elaborate signaling pathways activated by extracellular stimuli. The integrin family of cell surface receptors is known to activate intracellular pathways in response to signals generated via specific interactions with the extracellular matrix. Through the use of immunohistochemistry and immunoblotting, this study shows that the alpha-v beta-6 integrin is predominately expressed in epithelial cells in human preneoplastic, prostate intraepithelial neoplasia, proliferative inflammatory atrophy lesions and prostatic adenocarcinoma. The results indicate that alpha-v beta-6 is highly expressed in areas with infiltrating leukocytes, and is expressed focally in malignant and some benign prostate glands, but not in normal prostate tissue.
Files	MQP.pdf