Title page for E-project-042709-102523

Project Type	MQP
Submission date	2009-04-27
Authors	Helena C Alfonzo, BE Syed Moazzam Ali, BE Brian Joseph Almeida, BE Katie A Flynn, BE
URN	E-project-042709-102523
Title	Cardiac Scaffold for Human Mesenchymal Stem Cell Facilitated Autonomous Pacing
Advisor	Gaudette, Glenn R, BE
Availability	unrestricted
Abstract HCN gene modified Human Mesenchymal Stem Cells (hMSCs) have shown the ability to restore pacemaker function in canine and murine models. However, stem cell migration from the delivery site is a major concern. To address this problem, the team designed a device to prevent migration but still allow communication between the stem cells and native cardiomyocytes. Scaffold pore size, fiber diameter and biomaterial selection were necessary to determine. The team conducted a pore size migration assay, cell deflection calculations, gap junction formation assay and cell viability assays. The results from the tests led to the design of a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.
Files	Cardiac_Scaffold_for_Human_Mesenchymal_Stem_Facilitated_Autonomous_Pacing.pdf MQP_Final_Presetnation.pdf

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