Title page for E-project-042805-021631

Project Type MQP

Submission date 2005-04-28

Authors
Kristen Marie Kane, BE
Beth Marie Lorusso, BIO

URN E-project-042805-021631

Sponsor Tufts Veterinary School

Title Osteogenic potential of silk scaffold functionalized with growth factors

Advisors
Shivkumar, Satya, ME
Rulfs, Jill, BB

Availability unrestricted

Abstract
There is renewed interest in silks as a biomaterial due to their unique mechanical properties, highly organized structure, and diverse surface chemistry. This study investigates silk's efficacy as an alternative biomaterial for bone regeneration and analyzes the role of adhesion and signaling factors in the process. Femoral defects in rodents were implanted with a series of scaffold combinations. Parameters included scaffold decoration (RGD or BMP-2) and hMSCs. Radiological and DEXA analyses demonstrated that scaffolds with BMP-2 and empty scaffolds produced the most bone ingrowth and defect bridging.

Files
KMK_BML_MQP.pdf

Browse by Author | Browse by Department | Search all available E-projects

Questions? Email project-questions@wpi.edu
Maintained by webmaster@wpi.edu

Project Type	MQP
Submission date	2005-04-28
Authors	Kristen Marie Kane, BE Beth Marie Lorusso, BIO
URN	E-project-042805-021631
Sponsor	Tufts Veterinary School
Title	Osteogenic potential of silk scaffold functionalized with growth factors
Advisors	Shivkumar, Satya, ME Rulfs, Jill, BB
Availability	unrestricted
Abstract There is renewed interest in silks as a biomaterial due to their unique mechanical properties, highly organized structure, and diverse surface chemistry. This study investigates silk's efficacy as an alternative biomaterial for bone regeneration and analyzes the role of adhesion and signaling factors in the process. Femoral defects in rodents were implanted with a series of scaffold combinations. Parameters included scaffold decoration (RGD or BMP-2) and hMSCs. Radiological and DEXA analyses demonstrated that scaffolds with BMP-2 and empty scaffolds produced the most bone ingrowth and defect bridging.
Files	KMK_BML_MQP.pdf