Worcester Polytechnic Institute Electronic Projects Collection

Title page for E-project-042811-165338


Project TypeMQP
Submission date2011-04-28
Author
  • Timothy Daniel Bonci, BIO
  • URNE-project-042811-165338
    SponsorJuerg Straubhaar & Mira Jakovcevski
    TitleCluster visualization of upregulated HDAC1 in mouse using integration of Treeview and Galaxy
    Advisor
  • Ryder, Elizabeth F., BB
  • Availability unrestricted

    Abstract

    In order to better understand genetic expression changes in experiments, microarray data is computer analyzed by tools such as the freely available Galaxy, which currently lacks microarray visualization.160 A visualization interface was built into the toolset using Python.160 It was enabled with selectable clustering algorithms which were used to analyze the RNA from mice infected with AAV to upregulate HDAC1 or LacZ.160 The HDAC enzymes have been shown to play a part in the negative regulation of types of learning. This clustering identifies other genes as likely actors in the chemistry of memory and learning.

    Files
  • BonciMQP.pdf

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