Title page for E-project-042811-165338

Project Type MQP

Submission date 2011-04-28

Author
Timothy Daniel Bonci, BIO

URN E-project-042811-165338

Sponsor Juerg Straubhaar & Mira Jakovcevski

Title Cluster visualization of upregulated HDAC1 in mouse using integration of Treeview and Galaxy

Advisor
Ryder, Elizabeth F., BB

Availability unrestricted

Abstract
In order to better understand genetic expression changes in experiments, microarray data is computer analyzed by tools such as the freely available Galaxy, which currently lacks microarray visualization.160 A visualization interface was built into the toolset using Python.160 It was enabled with selectable clustering algorithms which were used to analyze the RNA from mice infected with AAV to upregulate HDAC1 or LacZ.160 The HDAC enzymes have been shown to play a part in the negative regulation of types of learning. This clustering identifies other genes as likely actors in the chemistry of memory and learning.

Files
BonciMQP.pdf

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Project Type	MQP
Submission date	2011-04-28
Author	Timothy Daniel Bonci, BIO
URN	E-project-042811-165338
Sponsor	Juerg Straubhaar & Mira Jakovcevski
Title	Cluster visualization of upregulated HDAC1 in mouse using integration of Treeview and Galaxy
Advisor	Ryder, Elizabeth F., BB
Availability	unrestricted
Abstract In order to better understand genetic expression changes in experiments, microarray data is computer analyzed by tools such as the freely available Galaxy, which currently lacks microarray visualization.160 A visualization interface was built into the toolset using Python.160 It was enabled with selectable clustering algorithms which were used to analyze the RNA from mice infected with AAV to upregulate HDAC1 or LacZ.160 The HDAC enzymes have been shown to play a part in the negative regulation of types of learning. This clustering identifies other genes as likely actors in the chemistry of memory and learning.
Files	BonciMQP.pdf