Title page for E-project-043009-084812

Project Type	MQP
Submission date	2009-04-30
Author	Lujain F Al Sowaimel, lujain@WPI.EDU, BC
URN	E-project-043009-084812
Sponsor	none
Title	Artemisinin Yields in Chinese and Yugoslavian Strains of Artemisia annua
Advisor	Wobbe, Kristin K, CH
Availability	unrestricted
Abstract The most effective treatment against malaria is artemisinin (AN), which is extracted from Artemisia annua. Considerable differences in the content of AN and its direct precursors are found in various A. annua plants of different geographical origins. From previous studies, AN yield in the Chinese (CH) strain is consistent and high compared to the Yugoslavian (YU) strain where the yield is lower and highly variable. Two possible causes of variability of AN content in the YU strain are reactive oxygen species (ROS) and AN precursor levels which are analyzed using a simple colorimetric method and liquid chromatography-mass spectrometry, respectively. There was no difference in H2O2 levels in either strain; the main cause of the low AN level in the YU strain is the precursor levels.
Files	MQPproject.pdf There is one file which has been withheld at the advisor's request.

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