Title page for E-project-043009-093314

Project Type MQP

Submission date 2009-04-30

Authors
Stephanie L Carlyle, BE
Elizabeth Glasson, BE
Teresa A Nowak, BE
Valentina S Polyakova, BE

URN E-project-043009-093314

Title Design of a Bioreactor for Myocardial Patch Generation

Advisor
Rolle, Marsha W., BE

Availability unrestricted

Abstract
Heart disease is the leading cause of death in the United States, leaving the afflicted with lost or damaged cardiac tissue. Current repair methods include synthetic and extra cellular matrix patches. Cell-derived patches seek to improve on current methods, but production processes are difficult. The goal of this project was to design an improved bioreactor to generate multiple totally cell-derived patches. A bioreactor was designed to allow the production of tissue patches without user intervention. A controllable media distributor circulates media throughout the system that has the ability to generate 12 tissue patches per trial. This automated, versatile device fits in a tissue culture incubator and is compatible with a variety of human cell types for clinical and experimental use.

Files
Bioreactor_for_Myocardial_Patch_Generation.pdf

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Project Type	MQP
Submission date	2009-04-30
Authors	Stephanie L Carlyle, BE Elizabeth Glasson, BE Teresa A Nowak, BE Valentina S Polyakova, BE
URN	E-project-043009-093314
Title	Design of a Bioreactor for Myocardial Patch Generation
Advisor	Rolle, Marsha W., BE
Availability	unrestricted
Abstract Heart disease is the leading cause of death in the United States, leaving the afflicted with lost or damaged cardiac tissue. Current repair methods include synthetic and extra cellular matrix patches. Cell-derived patches seek to improve on current methods, but production processes are difficult. The goal of this project was to design an improved bioreactor to generate multiple totally cell-derived patches. A bioreactor was designed to allow the production of tissue patches without user intervention. A controllable media distributor circulates media throughout the system that has the ability to generate 12 tissue patches per trial. This automated, versatile device fits in a tissue culture incubator and is compatible with a variety of human cell types for clinical and experimental use.
Files	Bioreactor_for_Myocardial_Patch_Generation.pdf