Title page for E-project-043009-121038

Project Type MQP

Submission date 2009-04-30

Author
Morgan E Oexner, ID

URN E-project-043009-121038

Sponsor Abbott Bioresearch Center

Title Cell Surface Phenotype of CNS Infiltrate and Resident Microglia During the Course of Relapsing Experimental Autoimmune Encephalomyelitis in Mice

Advisor
Rulfs, Jill, BB

Availability restricted

Abstract
Multiple Sclerosis (MS) is the most common cause of neurological disability in young adults. In this study, the animal model of MS, experimental autoimmune encephalomyelitis (EAE) was used in conjunction with tissue harvest techniques, flow cytometry and an ex vivo assay system in order to immunophenotype cellular infiltrate over the course of disease, study microglial activation, evaluate the ability of microglia to stimulate T-cells and to determine the effects of small molecule inhibitors on certain biochemical pathways. This study demonstrates that CNS infiltrate kinetics mirror disease course and suggests that microglia be involved in antigen presentation and effector function during disease course.

Files
Oexner_MQP.pdf
There is one file which has been withheld at the advisor's request.
indicates that a file or directory is accessible from the WPI campus network only.

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Project Type	MQP
Submission date	2009-04-30
Author	Morgan E Oexner, ID
URN	E-project-043009-121038
Sponsor	Abbott Bioresearch Center
Title	Cell Surface Phenotype of CNS Infiltrate and Resident Microglia During the Course of Relapsing Experimental Autoimmune Encephalomyelitis in Mice
Advisor	Rulfs, Jill, BB
Availability	restricted
Abstract Multiple Sclerosis (MS) is the most common cause of neurological disability in young adults. In this study, the animal model of MS, experimental autoimmune encephalomyelitis (EAE) was used in conjunction with tissue harvest techniques, flow cytometry and an ex vivo assay system in order to immunophenotype cellular infiltrate over the course of disease, study microglial activation, evaluate the ability of microglia to stimulate T-cells and to determine the effects of small molecule inhibitors on certain biochemical pathways. This study demonstrates that CNS infiltrate kinetics mirror disease course and suggests that microglia be involved in antigen presentation and effector function during disease course.
Files	Oexner_MQP.pdf There is one file which has been withheld at the advisor's request. indicates that a file or directory is accessible from the WPI campus network only.