Title page for E-project-043009-121244

Project Type MQP

Submission date 2009-04-30

Authors
Haseeb Ahmed Ali, ME
Jay T Breindel, ME
Samantha L Bullock, BB
Jesse T Herrera, ME

URN E-project-043009-121244

Title Vessel Ring Bioreactor

Advisors
Billiar, Kristen, BE
Rolle, Marsha W., BE
Overstrom, Eric W., BB

Availability restricted

Abstract
Cyclic loading is an important stimulus for creating mechanically stable tissue engineered blood vessels. The goal of this work is to create a device that dynamically conditions rings of vascular tissue created by cells in culture without the use of a scaffold. To create a high-throughput and accurate yet inexpensive device, a regulated pressure source and electronic valve controller were utilized to cyclically inflate up to 32 ring segments cultured on a series of silicone tubes encased in standard sterile conical tubes. This device will be used to determine the dynamic culture conditions that optimize engineered vessel growth and maturation in culture.

Files
Biology_Vessel_Ring_Bioreactor.pdf
Mechanical_Vessel_Ring_Bioreactor.pdf
There is one file which has been withheld at the advisor's request.
indicates that a file or directory is accessible from the WPI campus network only.

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Project Type	MQP
Submission date	2009-04-30
Authors	Haseeb Ahmed Ali, ME Jay T Breindel, ME Samantha L Bullock, BB Jesse T Herrera, ME
URN	E-project-043009-121244
Title	Vessel Ring Bioreactor
Advisors	Billiar, Kristen, BE Rolle, Marsha W., BE Overstrom, Eric W., BB
Availability	restricted
Abstract Cyclic loading is an important stimulus for creating mechanically stable tissue engineered blood vessels. The goal of this work is to create a device that dynamically conditions rings of vascular tissue created by cells in culture without the use of a scaffold. To create a high-throughput and accurate yet inexpensive device, a regulated pressure source and electronic valve controller were utilized to cyclically inflate up to 32 ring segments cultured on a series of silicone tubes encased in standard sterile conical tubes. This device will be used to determine the dynamic culture conditions that optimize engineered vessel growth and maturation in culture.
Files	Biology_Vessel_Ring_Bioreactor.pdf Mechanical_Vessel_Ring_Bioreactor.pdf There is one file which has been withheld at the advisor's request. indicates that a file or directory is accessible from the WPI campus network only.