Title page for E-project-043009-122725

Project Type	MQP
Submission date	2009-04-30
Authors	Jo-Ellen J Sullivan, BIO An T Zacharia, BIO
URN	E-project-043009-122725
Sponsor	Biology and Biology Department
Title	Isolation and Characterization of Novel mig-10 Mutations
Advisors	Buckholt, Michael Allan, BB Ryder, Elizabeth F, BB
Availability	unrestricted
Abstract The purposes of this MQP were to identify and characterize novel missense mutations in the Caenorhabditis elegans gene mig-10 which cause defects in neuronal migration, axonal growth, and excretory cell growth. Because of its fully penetrant mutant phenotype characteristic in the null mutant, the truncated excretory canal phenotype was used as a genetic model for developmental axonal growth. The mutants RY0920, RY0921 and RY0922 were isolated by using a simple screen. RY0920 strain was confirmed as new allele of mig-10 by complementation test, PCR, and restriction digestion. Novel missense alleles of mig-10 can help to define MIG-10 protein domains and residues important for neuronal migration function in C. elegans.
Files	An_JoEllen-mig10-MQP-Final_draft.pdf

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