Title page for E-project-050109-103004

Project Type MQP

Submission date 2009-05-01

Author
Annie Vikart, CH

URN E-project-050109-103004

Title Synthesis of a Novel Multicyclic Organic Scaffold via a Photoinitiated Intramolecular Ylide-Alkene Cycloaddition Reaction

Advisor
Dittami, James P., CH

Availability unrestricted

Abstract
When developing potentially medicinally relevant compounds it is important to utilize efficient synthetic methods, control stereochemistry, liphophilicity, acidity, and the incorporation of bioisosteres. The synthesis of a bioisosteric analog of morphine was studied utilizing an intramolecular ylide-alkene cycloaddition as the final step to establish the six stereocenters and three of the rings of the molecule. This multicyclic scaffold is expected to produce biologically active compounds from a brief, modifiable synthesis and simple starting materials.

Files
AEV_MQP.pdf

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Project Type	MQP
Submission date	2009-05-01
Author	Annie Vikart, CH
URN	E-project-050109-103004
Title	Synthesis of a Novel Multicyclic Organic Scaffold via a Photoinitiated Intramolecular Ylide-Alkene Cycloaddition Reaction
Advisor	Dittami, James P., CH
Availability	unrestricted
Abstract When developing potentially medicinally relevant compounds it is important to utilize efficient synthetic methods, control stereochemistry, liphophilicity, acidity, and the incorporation of bioisosteres. The synthesis of a bioisosteric analog of morphine was studied utilizing an intramolecular ylide-alkene cycloaddition as the final step to establish the six stereocenters and three of the rings of the molecule. This multicyclic scaffold is expected to produce biologically active compounds from a brief, modifiable synthesis and simple starting materials.
Files	AEV_MQP.pdf