Title page for E-project-050409-144814

Project Type MQP

Submission date 2009-05-04

Authors
William Ernest Brown, bbrown@WPI.EDU, BB
Steven Richard Vessella, vessella@WPI.EDU, BIO
Benjamin Clark Webber, bcwebber@WPI.EDU, BC

URN E-project-050409-144814

Sponsor University of Massachusetts Medical School

Title Oral Avian Influenza Vaccine

Advisor
Adams, David S., BB

Availability unrestricted

Abstract
Avian influenza is a highly mutable RNA virus that is readily passed between bird
species, and from birds to humans. It is possibly the greatest airborne pandemic
threat to the human population. An inexpensive vaccine that is easy to produce,
store, and administer is necessary for the prevention of this disease. We purified
a novel protein construct (U65-mHAt) which includes the mature transcript of
Influenza A subtype H5N1 virus and loaded it into particles made of beta-glucan,
a known adjuvant that has been shown to improve immune system response to
the influenza vaccine. This system is cost effective, can be rapidly amplified, and
is easily administered making it a viable option for preventing a worldwide H5N1
pandemic.

Files
MQP_FINAL.pdf
There is one file which has been withheld at the advisor's request.

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Project Type	MQP
Submission date	2009-05-04
Authors	William Ernest Brown, bbrown@WPI.EDU, BB Steven Richard Vessella, vessella@WPI.EDU, BIO Benjamin Clark Webber, bcwebber@WPI.EDU, BC
URN	E-project-050409-144814
Sponsor	University of Massachusetts Medical School
Title	Oral Avian Influenza Vaccine
Advisor	Adams, David S., BB
Availability	unrestricted
Abstract Avian influenza is a highly mutable RNA virus that is readily passed between bird species, and from birds to humans. It is possibly the greatest airborne pandemic threat to the human population. An inexpensive vaccine that is easy to produce, store, and administer is necessary for the prevention of this disease. We purified a novel protein construct (U65-mHAt) which includes the mature transcript of Influenza A subtype H5N1 virus and loaded it into particles made of beta-glucan, a known adjuvant that has been shown to improve immune system response to the influenza vaccine. This system is cost effective, can be rapidly amplified, and is easily administered making it a viable option for preventing a worldwide H5N1 pandemic.
Files	MQP_FINAL.pdf There is one file which has been withheld at the advisor's request.