Project Type MQP Submission date 2009-05-04 Authors William Ernest Brown, BB Steven Richard Vessella, BIO Benjamin Clark Webber, BC URN E-project-050409-144814 Sponsor University of Massachusetts Medical School Title Oral Avian Influenza Vaccine Advisor Adams, David S., BB Availability unrestricted
Avian influenza is a highly mutable RNA virus that is readily passed between bird species, and from birds to humans. It is possibly the greatest airborne pandemic threat to the human population. An inexpensive vaccine that is easy to produce, store, and administer is necessary for the prevention of this disease. We purified a novel protein construct (U65-mHAt) which includes the mature transcript of Influenza A subtype H5N1 virus and loaded it into particles made of beta-glucan, a known adjuvant that has been shown to improve immune system response to the influenza vaccine. This system is cost effective, can be rapidly amplified, and is easily administered making it a viable option for preventing a worldwide H5N1 pandemic.
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