Title page for E-project-051007-182436

Project Type MQP

Submission date 2007-05-10

Authors
Gharam Han, BIO
Thomas G Hayes, BE
Michael P Riccio, BIO
Cem Saracel, BE

URN E-project-051007-182436

Title Design of a Scalable Method to Produce Cardiogenic Cells from hMSCs through Embryoid Body Formation and PDGF Treatment

Advisors
Ryder, Elizabeth F, BB
Gaudette, Glenn R, BE

Availability unrestricted

Abstract
This project developed a scalable method to produce cardio-myocytes from human mesenchymal stem cells (hMSCs) for use as a therapy for myocardial infarctions. Embryoid bodies (EBs) formed from hMSCs produced cardiac cells. To increase the production of EBs, a non-adhesive well structure was developed and tested. To increase the percentage of cardiac cells resulting from the process, platelet derived growth factor was used as a supplement. These novel methods will ease the process and increase the yield of cardiac cells.

Files
MQPPaper.pdf

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Project Type	MQP
Submission date	2007-05-10
Authors	Gharam Han, BIO Thomas G Hayes, BE Michael P Riccio, BIO Cem Saracel, BE
URN	E-project-051007-182436
Title	Design of a Scalable Method to Produce Cardiogenic Cells from hMSCs through Embryoid Body Formation and PDGF Treatment
Advisors	Ryder, Elizabeth F, BB Gaudette, Glenn R, BE
Availability	unrestricted
Abstract This project developed a scalable method to produce cardio-myocytes from human mesenchymal stem cells (hMSCs) for use as a therapy for myocardial infarctions. Embryoid bodies (EBs) formed from hMSCs produced cardiac cells. To increase the production of EBs, a non-adhesive well structure was developed and tested. To increase the percentage of cardiac cells resulting from the process, platelet derived growth factor was used as a supplement. These novel methods will ease the process and increase the yield of cardiac cells.
Files	MQPPaper.pdf