Title page for E-project-051707-143101

Project Type MQP

Submission date 2007-05-17

Author
Christopher Thomas Vacher, BIO

URN E-project-051707-143101

Title Antibodies Indicate Acetylcholine Receptors in Limulus Neromuscular Junctions

Advisor
Gibson, Daniel G, BB

Availability unrestricted

Abstract
Binding of antibodies to Acetylcholine receptors (AChR) on skeletal muscle prevents or weakens contraction, as in the human autoimmune disease Myasthenia Gravis (MG), also inducible in rats. The horseshoe crab (Limulus polyphemus), an ancient arthropod, is an unlikely candidate for neuromuscular control by acetylcholine because most arthropods' muscles are innervated by glutamatergic (excitatory) and GABAergic (inhibitory) neurons. Nevertheless, monoclonal anti-human AChR antibody caused eserine-reversible paralysis in Limulus larvae and juveniles, and in severed legs.

Files
MQP.pdf

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Project Type	MQP
Submission date	2007-05-17
Author	Christopher Thomas Vacher, BIO
URN	E-project-051707-143101
Title	Antibodies Indicate Acetylcholine Receptors in Limulus Neromuscular Junctions
Advisor	Gibson, Daniel G, BB
Availability	unrestricted
Abstract Binding of antibodies to Acetylcholine receptors (AChR) on skeletal muscle prevents or weakens contraction, as in the human autoimmune disease Myasthenia Gravis (MG), also inducible in rats. The horseshoe crab (Limulus polyphemus), an ancient arthropod, is an unlikely candidate for neuromuscular control by acetylcholine because most arthropods' muscles are innervated by glutamatergic (excitatory) and GABAergic (inhibitory) neurons. Nevertheless, monoclonal anti-human AChR antibody caused eserine-reversible paralysis in Limulus larvae and juveniles, and in severed legs.
Files	MQP.pdf