Title page for E-project-121206-175535

Project Type MQP

Submission date 2006-12-12

Authors
Martin Bazinet, BIO
Jessica Marie Blanchette, BIO

URN E-project-121206-175535

Title Caspase Activity in Valvular Interstitial Cells

Advisor
Rulfs, Jill, BB

Availability unrestricted

Abstract
The aim of this study was to determine whether the apparent reduction in cell number and alpha-SMA expression of porcine mitral valvular interstitial cells plated on substrates of varying stiffness was due to apoptosis or dedifferentiation. This decrease was determined to be a result of apoptosis as indicated by caspase levels comparable to the positive control. A more thorough investigation into cellular communication and signaling will be invaluable to the development of next generation valve replacements.

Files
MQPFINAL.pdf

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Project Type	MQP
Submission date	2006-12-12
Authors	Martin Bazinet, BIO Jessica Marie Blanchette, BIO
URN	E-project-121206-175535
Title	Caspase Activity in Valvular Interstitial Cells
Advisor	Rulfs, Jill, BB
Availability	unrestricted
Abstract The aim of this study was to determine whether the apparent reduction in cell number and alpha-SMA expression of porcine mitral valvular interstitial cells plated on substrates of varying stiffness was due to apoptosis or dedifferentiation. This decrease was determined to be a result of apoptosis as indicated by caspase levels comparable to the positive control. A more thorough investigation into cellular communication and signaling will be invaluable to the development of next generation valve replacements.
Files	MQPFINAL.pdf