Project Type MQP Submission date 2006-12-14 Author Donna Davidson, BIO URN E-project-121406-114733 Title Inhibition of HIV-1 Tat Induced Inflammation by the NF-kB Subunit RelB Advisor Adams, David S., BB Availability unrestricted Abstract
The NF-kappaB (NF-kB)/Rel family of transcription factors serves an important regulatory role in the production of immune responses and inflammation. The NF-kB family member RelB displays unusual properties in comparison to the other family members, as it exudes inhibitory effects on the pathway along with its traditional function of transcription initiation. Luciferase assays and TNFa ELISAs were used to determine if RelB represses transcriptional activity of NF-kB in a subunit-specific manner, and also to determine if RelB is able to attenuate NF-kB activity in response to HIV-encoded Tat. This in turn would lead to decreased TNFa synthesis. The outcome may have therapeutic potential in the context of neuroAIDS.
Files DonnaDavidsonMQP.pdf
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