Project Type MQP Submission date 2005-12-15 Author Andrew I Gagnon, BIO URN E-project-121505-033950 Center Worcester, MA Sponsor Abbott Bioresearch Center Title Kinase Characterization and HTRF Assay Development Advisor Adams, David S., BB Availability unrestricted
Abbott Bioresearch Center strives to characterize specific kinases in order to better understand the processes that take place in cells of the human body. The goal is to develop an inhibiting drug for a kinase pathway associated with a particular target disease. The main focus at Abbott is autoimmune diseases, including rheumatoid arthritis and pro-inflammatory diseases. This MQP details the initial process that each kinase goes through in order to understand compound inhibition under conditions that take into consideration the effects of a physiological environment, and shows the application to one specific kinase, COT. An inhibitor of the kinase was identified that acts in an ATP-competitive manner. These processes allow for screening of thousands of compounds against any kinase that can be isolated and characterized.
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