Worcester Polytechnic Institute Electronic Theses and Dissertations Collection

Title page for ETD etd-012914-205752


Document Typedissertation
Author NameKashuri, Klaida
Email Address klaida at wpi.edu
URNetd-012914-205752
TitleCalorimetric and Dielectric Studies of Self-assembled Bio-molecules in an Aqueous Environment
DegreePhD
DepartmentPhysics
Advisors
  • Germano S. Iannacchione, Advisor
  • Izabela Stroe, Committee Member
  • Georgi Georgiev, Committee Member
  • Keywords
  • protein dynamics
  • bio-physics
  • calorimetry measurements
  • dielectric spectroscopy
  • Date of Presentation/Defense2013-11-26
    Availability unrestricted

    Abstract

    Self-assembly and the induced orientation of microscopic biological systems is of great scientific interest, because it holds the promise of many

    pharmaceutical applications. This dissertation presents experimental studies done on proteins, short DNA fragments, and cholesterol structures self-assembled in an aqueous environment. The goal is to probe the thermo-physical properties of these systems, their phases and phase transitions, in order to better under-stand the principles behind their unique assemblies and function. It is

    accepted that in all these systems the solvent water plays an important role on the assembly folding, orientation, and activity of biopolymers. However, the abundance of water in typical samples presents many experimental challenges. It is indeed the case that changes in the properties of hydration in watery

    environments are responsible for the dynamics of protein and DNA

    biomolecules. We have explored in more detail the thermodynamics, the structural properties, and the dynamics near structural transitions of biomolecules in their native aqueous environment.

    Files
  • Dissertation_KK.pdf

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