Worcester Polytechnic Institute Electronic Theses and Dissertations Collection

Title page for ETD etd-020606-165721


Document Typethesis
Author NameBiyikli, Kasim
URNetd-020606-165721
TitleNucleation and Growth of Crystals of Pharmaceuticals on Functionalized Surfaces
DegreeMS
DepartmentChemistry & Biochemistry
Advisors
  • John C. MacDonald, Advisor
  • Keywords
  • crystal growth
  • monolayer
  • polymorph
  • Date of Presentation/Defense2005-05-16
    Availability unrestricted

    Abstract

    A series of hydrophobic and hydrophilic self-assembled

    monolayers (SAMs) were deposited by the adsorption of 1-

    dodecanethiol (SAM I), 11-mercapto-1-undecanol (SAM II), 16-

    mercaptohexadecanoic acid (SAM III), 5-(10-mercaptodecyloxy)

    benzene-1,3-dioic acid (SAM IV) and 4-(10-mercaptodecyloxy)-

    pyridine-2,6-dicarboxylic acid (SAM V) on gold substrates.

    Crystallization experiments were carried out on SAMs I-V, on

    control surfaces (bulk gold, glass and PDMS

    (polydimethlysiloxane)) and in microfluidic devices to screen the

    polymorphs of two well known drugs, acetaminophen and

    barbital. Microfluidic devices consist of PDMS

    (polydimethlysiloxane) patterned with microchannels and then

    bonded to self-assembled monolayers (SAMs) of organic

    molecules on gold substrates. The crystallization of

    acetaminophen was carried out under thermodynamic conditions

    from solutions at room temperature and under kinetic

    conditions by rapid cooling. The results of crystallization

    experiments and the influence of self-assembled monolayers

    (SAMs) in controlling polymorphism by acting as nucleation

    sites, or templates, are discussed.

    Files
  • Kasim_Biyikli_MS_Thesis.pdf

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