Document Type thesis Author Name Jaimes, Rafael Email Address rafjaimes at gmail.com URN etd-051911-012047 Title Spatiotemporal Organization of Atrial Fibrillation Using Cross-Bicoherence with Surrogate Data Degree MS Department Biomedical Engineering Advisors Ki Chon, Advisor David McManus, Committee Member Domhnull Granquist-Fraser, Committee Member Keywords atrial fibrillation cardiac electrophysiology cross-bispectrum cross-bicoherence high order spectral analysis surrogate data Date of Presentation/Defense 2011-05-19 Availability unrestricted
Atrial fibrillation (AF) is a troublesome disease often overlooked by more serious myocardial infarctions. Up until now, there has been very little or no use of high order spectral techniques in order to evaluate the organization of the atrium during AF. Cross-bicoherence algorithm can be used alongside a surrogate data threshold in order to determine significant phase coupling interactions, giving rise to an organizational metric. This proposed algorithm is used to show rotigaptide, a gap junction coupling drug, significantly increases the organization of the atria during episodes of AF due to improvement of cell-to-cell coupling.
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