Title page for ETD etd-051911-012047

Document Type	thesis
Author Name	Jaimes, Rafael
Email Address	rafjaimes at gmail.com
URN	etd-051911-012047
Title	Spatiotemporal Organization of Atrial Fibrillation Using Cross-Bicoherence with Surrogate Data
Degree	MS
Department	Biomedical Engineering
Advisors	Ki Chon, Advisor David McManus, Committee Member Domhnull Granquist-Fraser, Committee Member
Keywords	atrial fibrillation cardiac electrophysiology cross-bispectrum cross-bicoherence high order spectral analysis surrogate data
Date of Presentation/Defense	2011-05-19
Availability	unrestricted
Abstract Atrial fibrillation (AF) is a troublesome disease often overlooked by more serious myocardial infarctions. Up until now, there has been very little or no use of high order spectral techniques in order to evaluate the organization of the atrium during AF. Cross-bicoherence algorithm can be used alongside a surrogate data threshold in order to determine significant phase coupling interactions, giving rise to an organizational metric. This proposed algorithm is used to show rotigaptide, a gap junction coupling drug, significantly increases the organization of the atria during episodes of AF due to improvement of cell-to-cell coupling.
Files	Jaimes_Masters.pdf

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