Current Projects
Designing Biomaterials to Direct Keratinocyte Function: A Multi-Scale Approach
We developed methods to create basal lamina analogs with precise topographical features that facilitate the formation of an epidermal layer on the surface of a dermal analog. We are investigating methods to modify the surface biochemistries, in order to provide cell-signaling cues.
Endogenous Myocardial Regeneration
We have developed an in vitro system to induce adult myocytes to express cell cycle markers. We are investigating the mechanism responsible for inducing adult myocytes to proliferate.
Complex Tissue Regeneration
We are defining the factors that have the potential to de-differentiate human wound fibroblasts into stem-like cells. These cells may be able to skew healing outcome from scar formation to regeneration of functional tissue.
Cell-mediated remodeling of 3-D matrices
We are studying cell-mediated tissue remodeling in response to biomechanical (cyclic stretch) and biochemical stimulation (growth factors) by using model systems including fibrin and collagen gels.
Myofibroblast differentiation
Myofibroblasts are important for tissue healing and wound closure. We are studying the effects of mechanical and biochemical environments on fibroblast-to-myofibroblast differentiation.
Fracture Fixation
Boney healing is optimized when proper fixation between bone segments is achieved. We are currently investigating rigid fixation devices for sternal closure and self-tightening devices for joint fusion.
Maintained by webmaster@wpi.eduLast modified: January 21, 2009 11:25:52