Origins and characteristics of bioelectric signals, recording electrodes, biopotential amplifiers, basic sensors, chemical, pressure, sound, and flow transducers, noninvasive monitoring techniques and electrical safety. (Prerequisites: Circuits and electronics, control engineering or equivalent.)
Biomaterials are an integral part of medical devices, implants, controlled drug delivery systems, and tissue engineered constructs. Extensive research efforts have been expended on understanding how biologic systems interact with biomaterials. Meanwhile, controversy has revolved around biomaterials and their availability as a result of the backlash to the huge liability resulting from controversies related to material and processing shortcomings of medical devices. This course specifically addresses the unique role of biomaterials in medical device design and the use of emerging biomaterials technology in medical devices. The need to understand design requirements of medical devices based on safety and efficacy will be addressed. Unexpected device failure can occur if testing fails to account for synergistic interactions from chronic loading, aqueous environments, and biologic interactions. Testing methodologies are readily available to assess accelerated effects of loading in physiologic-like environments. This combined with subchronic effects of animal implants is a potential tool in assessing durability. It is difficult to predict the chronic effects of the total biologic environment. The ultimate determination of safety comes not only from following the details of regulations, but with an understanding of potential failure modes and designs that lowers the risk of these failures. This course will evaluate biomaterials and their properties as related to the design and reliability of medical devices.
This course provides an overview of regulations that guide the medical devices industry. Primary focus is on the Food, Drug and Cosmetic Act (FD&C Act) and its associated regulations. The course covers the FD&C Act, including definitions, prohibited acts, penalties and general authority. The course also covers regulations, including establishment registration, premarket approval (PMA) and current good manufacturing practices. Requirements of other federal agencies (NRC, FCC, EPA) will also be discussed.
This biomaterials course focuses on the selection, processing, testing and performance of materials used in biomedical applications with special emphasis upon tissue engineering. Topics include material selection and processing, mechanisms and kinetics of material degradation, cell-material interactions and interfaces; effect of construct architecture on tissue growth; and transport through engineered tissues. Examples of engineering tissues for replacing cartilage, bone, tendons, ligaments, skin and liver will be presented. (Recommended preparation: A first course in biomaterials equivalent to ME/BME 4814 and a basic understanding of physiology and cell biology.)
This biomechanics course focuses on advanced techniques for the characterization of the structure and function of hard and soft tissues and their relationship to physiological processes. Applications include tissue injury, wound healing, the effect of pathological conditions upon tissue properties, and design of medical devices and prostheses. (Prerequisite: An understanding of basic continuum mechanics.)
An introduction to fundamental principles in cell biology and physiology designed to provide the necessary background for advanced work in biomedical engineering. Quantitative methods of engineering and the physical sciences are stressed. Topics include cell biology, DNA technology and the physiology of major organ systems. NOTE: This course can be used to satisfy a life science requirement in the biomedical engineering program. It cannot be used to satisfy a biomedical engineering course requirement.
A study of anesthesia, surgical techniques and postoperative care in small laboratory animals. Anatomy and physiology of species used included as needed. Class limited to 15 students. Approximately 15 surgical exercises are performed by each student. (Prerequisite: Graduate standing. Admission of undergraduate students requires the permission of the department head and the instructor.) NOTE: This course can be used to satisfy a life science requirement in the biomedical engineering program. It cannot be used to satisfy a biomedical engineering course requirement.
Topics in biomedical engineering are presented both by authorities in the field and graduate students in the program. Provides a forum for the communication of current research and an opportunity for graduate students to prepare and deliver oral presentations. Students may meet the attendance requirement for this course in several ways, including attendance at weekly biomedical engineering seminars on the WPI campus, attendance at similar seminar courses at other universities or biotech firms, attendance at appropriate conferences, meetings or symposia, or in any other way deemed appropriate by the course instructor.
Topics in biomedical engineering. Presentations and discussions of the current literature in an area of biomedical engineering. See the SUPPLEMENT section of the on-line catalog at www.wpi. edu/+gradcat for descriptions of courses to be offered in this academic year.