Chemistry and Biochemistry
The emphasis is on using a variety of spectroscopic data to arrive at molecular structures, particularly of organic molecules. Major emphasis is on H- and C-NMR, IR and MS. There is relatively little emphasis on theory or on sampling handling techniques.
This course emphasizes the fundamental aspects of 1D and 2D nuclear magnetic resonance spectroscopy (NMR). The theory of pulsed Fourier transform NMR is presented through the use of vector diagrams. A conceptual nonmathematical approach is employed in discussion of NMR theory. The course is geared toward an audience which seeks an understanding of NMR theory and an appreciation of the practical applications of NMR in chemical analysis. Students are exposed to hands-on NMR operation. Detailed instructions are provided and each student is expected to carry out his or her own NMR experiments on a Bruker AVANCE 400 MHz NMR spectrometer.
This course will focus on the medicinal chemistry aspects of drug discovery from an industrial pharmaceutical research and development perspective. Topics will include Chemotherapeutic Agents (such as antibacterial, antiviral and antitumor agents) and Pharmacodynamic Agents (such as antihypertensive, antiallergic, antiulcer and CNS agents). Pre-requisite: A good foundation in organic chemistry, e.g., CH 2310 Organic Chemistry I and CH 2320 Organic Chemistry II.
This course covers the biochemical mechanisms involved in regulation of gene expression: modifications of DNA structures that influence transcription rates, transcriptional regulation, post-transcriptional processing of RNA including splicing and editing, nuclear/cytoplasmic transport, regulation of translation, and factors that control the half-lives of both mRNA and protein. During the course, common experimental methods are explored, including a discussion of the information available from each method.
This course will focus on different areas of biophysics with special emphasis on membrane phenomena. The biomedical-biological importance of biophysical phenomena will be stressed. The course will begin with an introduction to the molecular forces relevant in biological media and subsequently develop the following topics: membrane structure and function; channels, carriers and pumps; nerve excitation and related topics; and molecular biophysics of motility. Topics will be developed assuming a good understanding of protein and lipid chemistry, enzyme kinetics, cell biology, and electricity.
This course trains students in the area of molecular modeling using a variety of quantum mechanical and force field methods. The approach will be toward practical applications, for researchers who want to answer specific questions about molecular geometry, transition states, reaction paths and photoexcited states. No experience in programming is necessary; however, a backround at the introductory level in quantum mechanics is highly desirable. Methods to be explored include density functional theory, ab initio methods, semiempirical molecular orbital theory, and visualization software for the graphical display of molecules.
A course of advanced study in selected areas whose content and format varies to suit the interest and needs of faculty and students. This course may be repeated for different topics covered. See the SUPPLEMENT section of the on-line catalog at www.wpi.edu/+gradcat for descriptions of courses to be offered in this academic year.
Reports on current advances in the various branches of chemistry.