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Life Sciences & Bioengineering Center, 3003
Phone: +1-508-831-4680

Domhnull Granquist-Fraser

Nature had solved many signal acquisition and processing problems long before humans first attempted to improve their ability to record and interpret the universe around them. The design and engineering of instrumentation for biomedical research is complemented by the utilization of biomorphic principles for instrumentation design; they inform each other.

My research covers both aspects of this relationship. In the first, I have developed optical and other electro-magnetic instrumentation for local and remote biometry: the measurement of biologically relevant signals. I have recently begun an investigation into the utility of using atomic magnetometry for the noninvasive measurement of extremely small signals generated by the body. In the second, I have drawn design principles from Nature’s solutions to engineer multi-aperture and space-variant imaging systems for super-resolution imaging and used the computational principles and structure of the retina to design an imager that produces velocity fields rather than illuminance images.

A new challenge that leverages these previous efforts is the design of ultra-wide field microscopes that exploit multiple apertures and super-resolution and image-stitching algorithmic techniques. At both the undergraduate and graduate levels of instruction and mentoring, my core aim is to cultivate a sense of physical intuition and insight, as these can often be absent if simulation has been exclusively utilized in learning design principles.

Outside the friendly confines of WPI, I remain a gearhead—building, modifying, and restoring both Jaguar automobiles and Moto Guzzi motorcycles. I am a complete and unapologetic tool addict. I am continually striving to improve my skills in the kitchen, and my daughter is my greatest joy.


  • BS, University of the State of New York, Regents College, 1995
  • Graduate Studies, Louisiana State University Medical Center, 1994-1996
  • PhD, Boston University, Cognitive and Neural Systems 2003
  • Post-Doctoral Studies, University of California, Berkeley 2000-2001

Featured Publications

  • Polimeni, J.L., Granquist-Fraser, D., Woods, R.J., and Schwartz, E.L., Physical limits to spatial resolution of optical recording: clarifying the spatial structure of cortical hypercolumns, Proceedings of the National Academy of Sciences of the United States of America, 102(11):4158-4163, 15 March 2005.
  • Karen A. Huyser, Kevin H. Knuth, Bernd Fischer, Johann Schumann, Domhnull Granquist-Fraser, and Arsen R. Hajian, Discovering Planetary Nebula Geometries: Explorations with a Hierarchy of Models, in Bayesian Inference and Maximum Entropy Methods in Science and Engineering, edited by Rainer Fischer, Roland Preuss and Udo von Toussaint, American Institute of Physics, Melville, NY, 2002, vol. 735, pp. 135-142 (2004).
  • J.K. Thompson, D.G. Fraser, C.M. Schor, R.D. Freeman, Binocular Gain Control in the Visual Cortex, Soc. Neurosci. Abstr., Vol. 27, Program No. 619.24, 2001.
  • D.G. Fraser and R.P. Bobbin, High Accuracy measurement of isolated OHC motility using laser transmission microinterferometry, poster paper presented at the Mid-Winter meeting of the Association for Research in Otolaryngology, St. Petersburg, Florida, February 5, 1996.

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Professional Highlights

  • NSF Fellow 1994-1996
  • USN MURI Fellow 1997-1999
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