Life Sciences & Bioengineering Center, 4012
Glenn R. Gaudette
- Associate Professor, Biomedical Engineering
- Affiliated with:
My research aims to develop a treatment for the millions of Americans suffering from myocardial infarction and other cardiovascular diseases. We are focused on regenerating mechanical and electrophysiological function in the heart. Our work has demonstrated the induction of adult cardiac myocytes into the cell cycle. We also have differentiated adult stem cells into cardiac myocytes. In addition, to confirm that the regenerated tissue is mechanically active, our lab has developed a method for accurately measuring regional function at very high spatial resolution in the heart. To deliver stem cells with high engraftment efficiency, our laboratory has developed a novel suture-based method. My research has been supported by government (National Institutes of Health), nonprofit (American Heart Association), and private agencies (Synovis Life Technologies). I have 18 years of experience in the cardiac research field, including 10 years in cardiac surgery research. I currently teach biomedical engineering design, biomechanics, physiology and tissue engineering.
- Tissue Engineering
- Cell Therapy
- Cell Delivery
- Cardiac Regeneration
- 1989 BS Mechanical Engineering University of Massachusetts at Dartmouth
- 1992 MS Mechanical Engineering Georgia Institute of Technology
- 2002 PhD Biomedical Engineering State University of New York at Stony Brook
- Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential. Proulx MK, Carey SP, Ditroia LM, Jones CM, Fakharzadeh M, Guyette JP, Clement AL, Orr RG, Rolle MW, Pins GD, Gaudette GR. J Biomed Mater Res A. 2011 Feb;96(2):301-12.
- Strategies for regeneration of heart muscle. Guyette JP, Cohen IS, Gaudette GR. Crit Rev Eukaryot Gene Expr. 2010;20(1):35-50.
- Applying controlled non-uniform deformation for in vitro studies of cell mechanobiology. Balestrini JL, Skorinko JK, Hera A, Gaudette GR, Billiar KL. Biomech Model Mechanobiol. 2010 Jun;9(3):329-44
- Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation. Kelly DJ, Rosen AB, Schuldt AJ, Kochupura PV, Doronin SV, Potapova IA, Azeloglu EU, Badylak SF, Brink PR, Cohen IS, Gaudette GR. Tissue Eng Part A. 2009 Aug;15(8):2189-201.
- Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage. Potapova IA, Doronin SV, Kelly DJ, Rosen AB, Schuldt AJ, Lu Z, Kochupura PV, Robinson RB, Rosen MR, Brink PR, Gaudette GR, Cohen IS. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2257-63.