Faculty Directory

Contact Information

Office:
Life Sciences & Bioengineering Center, 4005
Phone: +1-508-831-4109
Fax: +1-508-831-4121
rpage@wpi.edu

Raymond L. Page

Understanding the interplay between cells and their environment with respect to growth factor/cytokine signaling is becoming a powerful tool with which to control cell phenotype and has applications in regenerative medicine and wound healing. In our lab we study the effects of ambient oxygen tension and cell culture substrate on the effect of specific growth factors in determining the growth rate, state of differentiation, and regeneration potential of primary human cells. Environment-induced alterations of cell phenotype are studied in skeletal muscle wound models. We are also interested in the development of three-dimensional in vitro models of skeletal muscle formation and function. We have employed novel biopolymer microthread technologies developed in the BME Department to deliver these cells in vivo to study their regeneration potential. In addition, we also study the effect of cell culture environment and substrate related to the control of cell phenotype and stem cell differentiation using primary adult cells derived tissues such as bone marrow, skin, and skeletal muscle.

For undergraduate instruction, I enjoy relating the fundamentals of individual material properties and biological processes to the engineering of complex systems or processes to produce medically useful products. Coupling engineering principles with the inherent challenges of biological systems to understand and predict system behavior in the context of the capstone design experience is of particular interest. At the graduate level, I strive to create an environment where students are free to explore and develop their own independent ideas and concepts related to the overall research objectives. I encourage active collaboration and interaction with fellow colleagues involving diverse disciplines. I also enjoy participating in training and mentoring programs involving undergraduates from peer institutions and secondary education teachers to help bring current biotechnological concepts into their curriculum.

Research Interests

  • Tissue Regeneration
  • Cell Dedifferentiation and Differentiation
  • Natural Biopolymers
  • Cell Therapy

Education

  • BS, West Virginia University, 1987
  • MS, West Virginia University, 1989
  • PhD, Virginia Tech, 1993

Featured Publications

  • Page RL, Malcuit C, Vilner L, Vojtic I, Shaw S, Hedblom E, Hu J, Pins GD,Rolle MW, Dominko T. Restoration of skeletal muscle defects with adult human cells delivered on fibrin microthreads. Tissue Eng Part A. 2011 Nov;17(21-22):2629-40. Epub 2011 Aug 2. PubMed PMID: 21699414.
  • Ambady S, Malcuit C, Kashpur O, Kole D, Holmes WF, Hedblom E, Page RL, Dominko T. Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. Int J Dev Biol. 2010;54(11-12):1743-54. PubMed PMID: 21136380.
  • Page RL, Ambady S, Holmes WF, Vilner L, Kole D, Kashpur O, Huntress V, Vojtic I, Whitton H, Dominko T. Induction of stem cell gene expression in adult human fibroblasts without transgenes. Cloning Stem Cells. 2009 Sep;11(3):417-26. PubMed PMID: 19622035; PubMed Central PMCID: PMC2925031.
  • Curchoe CL, Zhang S, Yang L, Page R, Tian XC. Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle. Anim Reprod Sci. 2009 Dec;116(3-4):213-25. Epub 2009 Feb 11. PubMed PMID: 19282114.
  • Smith SL, Everts RE, Sung LY, Du F, Page RL, Henderson B, Rodriguez-Zas SL, Nedambale TL, Renard JP, Lewin HA, Yang X, Tian XC. Gene expression profiling of single bovine embryos uncovers significant effects of in vitro maturation, fertilization and culture. Mol Reprod Dev. 2009 Jan;76(1):38-47. Erratum in: Mol Reprod Dev. 2009 May;76(5):523. PubMed PMID: 18449896.
  • Nat Biotechnol. 2007 Jan;25(1):77-83. Risk assessment of meat and milk from cloned animals. Yang X, Tian XC, Kubota C, Page R, Xu J, Cibelli J, Seidel G Jr. PMID: 17211406

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