ANTEC 2011 Best Student/Technical Paper Award for the Medical Plastics& Interactive Poster Presentation
Meghan Pasquali won Best Technical Paper and Best Student Paper Award for the Medical Plastics Division in ANTEC 2011, May 3, 2011, Boston, MA. Her paper advised by Prof. Jianyu Liang and Prof. Satya Shivkumar is titled "Effects of Time and Template Pore Size on the Morphology of Polymer Nanostructures Formed with the Template Assisted Method". The abstract of the paper is below.
Effects of Time and Template Pore Size on the Morphology of Polymer Nanostructures Formed with the Template Assisted Method
Meghan Pasquali, Prof. Jianyu Liang, Prof. Satya Shivkumar
Abstract: The template assisted method is a simple, cost effective technique that can be used to fabricate polymer nanotubes. In this study, the solution wetting technique was used to form polystyrene elongated nanostructures in anodized aluminum oxide templates. The effects of time and template pore size were studied to determine the role each parameter plays in the final morphology. It was found that for PS solutions with high molecular weight polymer, hollow nanotubes can be formed for time periods <18 hr, whereas low molecular weight polymer forms solid nanorods. Additionally, relatively large pore diameters of ~200-300 nm are necessary to form nanotubes.
Also Haikun Xu won the fourth place out of 75 posters in the interactive poster presentation of ANTEC 2011. His research project on biomaterials nanotube fabrication advised by Prof. Satya Shivkumar is titled "Fabrication of Temperature-Responsive Pluronic F127 Nanotubes". The abstract is below.
Fabrication of Temperature-Responsive Pluronic F127 Nanotubes
Haikun Xu, Prof. Satya Shivkumar
Abstract: Synthetic hydrogels based on Pluronics have been widely used as novel biomaterials in diverse medical applications because Pluronic block copolymers (PBCs) can undergo a reversible sol-gel transition in response to temperature, which means they can self-assemble into micelles at concentrations above the critical micelle concentration (CMC) and critical micelle temperature (CMT). Recently, the use of PBCs as drug delivery vehicle to treat multidrug-resistant (MDR) cancers is a rapidly developing area for cancer chemotherapy. One of the problems encountered with the use of PBCs is that the micelles disassociate at low concentrations. In order to improve the stabilization of the Pluronic micelles, chemically cross-linked hydrogels composed of Pluronic F127, water-soluble tri-block copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), were synthesized by a photo-crosslinking method. In brief, Pluronic F127 and triethylamine were first dissolved in dichloromethane, then added acryloyl chloride in a drop-wise manner. The reaction was under stirring and nitrogen purging through the system at room temperature for 48 hours to form di-acrylated Pluronic F127 (DA PF127). The DA PF127 macromer was dissolved in deionized water to prepare a sol. In the template-assisted method, anodized aluminum oxide (AAO) nano templates were initially soaked in the sol, and crosslinked subsequently upon exposure to UV light. A diverse range of hydrogels with different cross-linking densities and mechanical strengths could be produced by controlling UV irradiation time. After crosslinking, the morphology of the Pluronic F127 nanostructures was examined by scanning and transmission electron microscopy. Swelling ratio and rheological behaviors of Pluronic hydrogels were investigated.
July 14, 2011